BI 002 Steven Potter Part 2: Brains in Dishes

 
 
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Find out more about Steve at his website.

Things mentioned during the show:

  • Papers we talked about:
    • Publishing negative results!
      • Wagenaar, D. A., Pine, J., & Potter, S. M. (2006). Searching for plasticity in dissociated cortical cultures on multi-electrode arrays. Journal of Negative Results in BioMedicine 5:16. Download
    • Solving the bursting neurons problem:
      • Wagenaar, D. A. Madhavan, R. Pine, J. and Potter, S. M. (2005) Controlling bursting in cortical cultures with closed-loop multi-electrode stimulation. J. Neuroscience 25: 680-68 Download
    • Training the cultured networks:
      • Chao, Z. C., Bakkum, D. J., & Potter, S. M. (2008). Shaping Embodied Neural Networks for Adaptive Goal-directed Behavior. PLoS Computational Biology, 4(3): e1000042. Online Open-Access paper, supplement, and movie.
      • Bakkum, D. J., Chao, Z. C. (Co-First Authors), & Potter, S. M. (2008). Spatio-temporal electrical stimuli shape behavior of an embodied cortical network in a goal-directed learning task. Journal of Neural Engineering, 5, 310-323. Download reprint (3MB PDF)
    • The richness of the bursting activity, and how to get good signals from neurons in dishes:
      • Wagenaar, D. A., Pine, J. and Potter, S. M. (2006). An extremely rich repertoire of bursting patterns during the development of cortical cultures. BMC Neuroscience 7:11.Reprint (2.79 MB PDF).
      • You can find tons (over 40GB) of data from that paper here.
  • Non-synaptic plasticity (what?!)
    • Bakkum, D. J., Chao, Z. C., & Potter, S. M. (2008). Long-term activity-dependent plasticity of action potential propagation delay and amplitude in cortical networks. PLoS One, 3(5), e2088. Online Open-Access paper.
  • DIY neuroscience: Backyard brains
  • Citizen neuroscience:
  • Follow Steve’s Instrucable projects.

Extra fun stuff